Carlos Alcaraz set up a semifinal meeting with Lorenzo Musetti at the Italian Open on Wednesday with a 6-4, 6-4 win over Jack Draper in the last eight, while women's world number one Aryna Sabalenka was knocked out.

Sabalenka recorded her tour-leading 31st victory this season on the Madrid clay, adding the WTA 1000 trophy to titles in Brisbane and Miami.

Aryna Sabalenka kept a historic Australian Open hat-trick on track Tuesday as she battled past Russian 27th seed Anastasia Pavlyuchenkova 6-2, 2-6, 6-3 in the quarter-finals.

Double-defending champion Sabalenka blew away Russian 17-year-old Mirra Andreeva 6-1, 6-2 in a ruthless display on the hottest day of the Melbourne tournament so far.

The world number one remained on track to win her third consecutive Melbourne Park title but only after a rollercoaster scrap that lasted more than two hours on Rod Laver Arena.

Thunder and lightning saw players and fans rushing for cover, with the heavy rain a headache for organisers who face a match backlog.

The first Grand Slam of the year gets under way at Melbourne Park as a 15-day event for the second year running, aimed at cutting down on late-night finishes.

The 26-year-old jumped above Poland's French Open champion Iga Swiatek thanks to year-end adjustments in the standings.

Aryna Sabalenka said Tuesday that she wants to cap off a stellar year by returning to the top of the world rankings.

With Roger Federer retired and Rafael Nadal struggling to get back on court due to injuries, Novak Djokovic was the last man of that golden generation standing at Flushing Meadows, but the Serb crashed out in the third round to Australian Alexei Popyrin.

"I'm speechless right now. So many times I thought I was so close to get the US Open title. It has always been a dream of mine and finally I got this beautiful trophy," said Sabalenka.

Sabalenka sent down 34 winners to the 13 of the 23-year-old American in the tie.

Aryna Sabalenka detailed her current tennis philosophy on Tuesday, with the three-time Cincinnati Masters semi-finalist revealing she's quick to forget about her losses.

Osaka returned to the tour this year after 15 months of maternity leave for her daughter who turns one on Tuesday.

Russian teenager Mirra Andreeva became the youngest Grand Slam semi-finalist since 1997 with a shock victory over second seed Aryna Sabalenka, who was struggling with an apparent illness, at the French Open on Wednesday.

The current Australian Open champion arrived at Roland Garros as a top contender.

Iga Swiatek swept past Coco Gauff to reach the Rome Open final on Thursday where Aryna Sabalenka will stand in her way of a third title and her bid to match a Serena Williams record.

Coming back from 1-3 down in the decider and saving three match points in total, Swiatek claimed a 7-5, 4-6, 7-6 (9/7) victory to secure the Madrid Open trophy for the first time.

"Today was the test of fire, no discomfort, feeling spectacular... from here, we'll be getting better."

Defending Madrid Open champions Carlos Alcaraz and Aryna Sabalenka both triumphed in their opening clashes in the Spanish capital on Friday to reach the third round.