Former winners Porto were drawn Friday to face Claudio Ranieri's Roma in the standout tie of the Europa League knockout phase play-offs, while Manchester United and Tottenham Hotspur were among the clubs to discover their potential opponents in the last 16.

Porto manager Sergio Conceicao said Arsenal boss Mikel Arteta insulted his family during the London club's penalty shootout win over the Portuguese side in their Champions League last-16 tie on Tuesday.

Appearing in a first knockout match in Europe's premier club competition for seven years, Arsenal struggled to break down an organised Porto defence before Galeno's stroke of brilliance in the 94th minute.

PSG drew 1-1 away to Group F winners Borussia Dortmund to go through as runners-up after Milan came from behind to beat Newcastle at St James' Park and eliminate Eddie Howe's side.

Sadio Mane grabs a hattrick as Liverpool demolished Porto 5-0 away in their Champions League round-of-16 tie on Wednesday.

Porto coach Nuno Espirito Santo leaves the club by mutual consent after one season in charge.

Iker Casillas set a new record when featuring for Porto in their Champions League last 16, second leg against Juventus on Tuesday as he made his 175th appearance in European competition.

Portuguese forward Gonçalo Guedes was on the verge of a reported 30 million euro ($32M) move from Benfica to Paris Saint Germain on Wednesday as the French side said he was undergoing a medical with them.

Borussia Dortmund set a new Champions League scoring record in a 2-2 draw against Real Madrid on Wednesday while FC Porto and Sevilla claimed the two remaining last-16 spots.

Former Real Madrid goalkeeper Iker Casillas has labelled Barcelona star Lionel Messi the opponent he has had the most difficulty facing.

Chelsea manager Jose Mourinho has said his side's difficult start to the season is the worst period in his career.

In the midst of a frustrating start to the season, Jose Mourinho returns to Portugal on Tuesday as Chelsea face his old side FC Porto in the Champions League.

Mourinho is glad to be presented with a reminder of his managerial abilities, with awards that pay tribute to his time at Porto, Chelsea, Inter and Real Madrid.

Bayern Munich coach Pep Guardiola compares Lionel Messi to Brazil legend Pele as he backs his former club Barcelona to win the Champions League.