Italy's Jasmine Paolini reached her first Grand Slam semi-final at the French Open on Wednesday after dumping out fourth seed Elena Rybakina 6-2, 4-6, 6-4.

"Due to a torn medial meniscus in his right knee (discovered during an MRI scan performed today), Novak Djokovic... has been forced to withdraw from the Roland Garros tournament," organisers said in a statement.

De Minaur had never got past the second round at the tournament before this year, winning just three of 10 matches.

The 24-time Grand Slam title winner made the last 16 by defeating Italy's Lorenzo Musetti in a bruising five-set epic which concluded at 3:07 am Sunday.

His four-hour 29-minute victory also allowed the 37-year-old world number one to equal Roger Federer's record of 369 Grand Slam match wins.

Wimbledon champion Alcaraz, who made the semi-finals at Roland Garros last year, scrambled to a 6-3, 6-4, 2-6, 6-2 second round victory over a player taking part in only his second Grand Slam main draw.

Djokovic, chasing a fourth title at Roland Garros and record 25th Grand Slam triumph, came through against 142nd-ranked French opponent Pierre-Hugues Herbert 6-4, 7-6 (7/3), 6-4.

They are six young Italians dressed as carrots who are at the French Open in a colourful attempt to inspire Sinner to victory.

"Of course, on paper it is not the best draw," Nadal said ahead of the match on Court Philippe Chatrier

"It feels really nice to be back and I'm just really grateful to be here in front of everybody," said Osaka.

Nadal, who has won the French Open 14 times and will celebrate his 38th birthday on June 3, faces world number four Alexander Zverev in the first round in Paris on Monday.

He said if Nadal was in the French Open draw, he could not be ruled out, despite his injury problems and growing competition from a younger generation.

World number five Zverev, also Foro Italico champion in 2017, comfortably won his sixth Masters 1000 title by beating Nicolas Jarry 6-4, 7-5 and is eyeing glory at the Paris clay-court Grand Slam, which gets underway next weekend.

In front of a packed centre court crowd Swiatek won her 36th match of the year and became the first woman since Serena Williams in 2013 to win at Madrid and Rome in the same season.

Djokovic said that his subdued performance on a court where he has won six titles might have been due to the blow suffered while greeting fans on Friday night.

Djokovic's bid for a record-extending 41st Masters 1000 title was ended in just over an hour by Chilean Tabilo, who is ranked 32nd in the world but was hugely impressive and claimed his first win over a top-10 opponent.

Defeat to seventh seed Hurkacz casts doubt over whether clay-court icon Nadal will play at the upcoming French Open, where he has won a record 14 titles.

"I have Roland Garros in just two weeks and a half... I need to prove myself if I am able to push my body to the limit, I need to push to feel myself ready for what's coming," Nadal told reporters.

The 22-time Grand Slam singles champion has recently returned to the circuit after a long absence due to injury.

Rublev, who takes the Madrid crown from double champion Carlos Alcaraz whom he beat in the quarter-finals, said he had played despite feeling ill at times this week and hailed his doctors for helping him through.