Theron noted that while male actors are frequently given second or third chances even after delivering box-office flops, women in similar positions are rarely afforded the same forgiveness.

Charlize Theron reprises her role as Andy and also serves as a producer. She leads a cast stacked with both returning favourites and new faces, including KiKi Layne, Matthias Schoenaerts, Marwan Kenzari, Luca Marinelli, Veronica Ngô, Henry Golding, Uma Thurman, and Chiwetel Ejiofor.