Australia's Nick Kyrgios sent defending champion Daniil Medvedev tumbling out of the US Open on Sunday as US teenager Coco Gauff reached the quarter-finals for the first time.

Serena Williams' dreams of a fairytale finish to her glittering career were dashed on Friday as the tennis icon was sent crashing out of the US Open by Australia's Ajla Tomljanovic.

Rafael Nadal overcame a freak injury scare when he accidentally hit himself with his own racquet to reach the US Open third round on Thursday.

The U.S. Open turned over Arthur Ashe Stadium to the Williams sisters on Thursday for a prime-time first round doubles match that could have been Serena's last after the pair fell 7-6 (5), 6-4 to the Czech duo of Lucie Hradecka and Linda Noskova.

World number one Daniil Medvedev maintained his strong start to his U.S. Open title defence on Wednesday, dispatching France's Arthur Rinderknech 6-2, 7-5, 6-3 in the Arthur Ashe Stadium to reach the third round.

Serena Williams roared into the third round of the US Open on Wednesday, overpowering second seed Anett Kontaveit with a battling performance to extend her Grand Slam singles career in dramatic fashion.

Emma Raducanu's U.S. Open title defence ended at the first hurdle on Tuesday while Wimbledon champion Elena Rybakina and twice U.S. Open winner Naomi Osaka were also ousted in the opening round.

Defending champion Emma Raducanu of Britain was sent crashing out of the US Open in the first round on Tuesday, losing in straight sets to France's Alize Cornet.

Four-time champion Rafael Nadal overcame dropping the first set to defeat Australian wildcard Rinky Hijikata at the US Open first round on Tuesday.

Daniil Medevedev launched the defence of his US Open crown on Monday with a straight sets victory over lowly ranked American Stefan Kozlov.

Colombian qualifier Daniel Galan stunned fourth-seeded Greek Stefanos Tsitsipas 6-0, 6-1, 3-6, 7-5 in an epic first-round showdown at the U.S. Open on Monday, winning the affair on the ninth match point.

Serena Williams said she is "staying vague" over her expected retirement from tennis after reaching the US Open second round on Monday.

After a glittering 27-year professional career in which she became one of the greatest players of all time, Serena Williams is preparing to bid farewell to tennis at the major where it all began.

A talented men's field is set for the 2022 U.S. Open, beginning on Monday. Flushing Meadows hosts the event with Rafael Nadal operating as the headline-grabbing player on the men's side.

Serena Williams held strong views on tennis, society as well as her rivals.

Rafael Nadal targets a fifth US Open and 23rd Grand Slam title in New York from next week with his path to the title no longer blocked by Novak Djokovic, whose refusal to get vaccinated has ruled him out of a second major this year.

Top seed Daniil Medvedev will open his U.S. Open title defence onMonday against American Stefan Kozlov but faces major hurdles on the path to a second Grand Slam title at Flushing Meadows, including in-form Australian Nick Kyrgios.

Serena Williams said on Tuesday she was "evolving away from tennis" and planned to retire from the sport she dominated with 23 Grand Slam titles following the U.S. Open tournament, which begins later this month.

Daniil Medvedev will arrive in New York for his U.S. Open title defence this month as the top seed after the Russian confirmed his stay as world number one by reaching the final in Los Cabos, Mexico on Friday.

Novak Djokovic said Saturday he is "preparing to compete" at the US Open even though his refusal to get vaccinated will see him barred from entering the country.